Pulsecor Research

Blood Pressure Plus…
Easy cardiovascular assessment.

pulsecor has an ongoing clinical research program spanning multiple institutions worldwide. These trials have shown that our technology is both sensitive to changes in physiology, and provides reliable results.

Since 2000 our technology has been trialed in environments ranging from the operating room, to the clinic, to the leisure centre.

In addition, we pride ourselves on “transparent-box” technology through an active program of theoretical research into the physical systems involved.

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Peer-Reviewed Literature relating to…

pulsecor (clinical)

· Payne RA, Isnardi D, Andrews PJD, Maxwell SRJ, Webb DJ. Similarity between the suprasystolic wideband external pulse wave and the first derivative of the intra-arterial pulse wave; British Journal of Anaesthesia 2007; 99(5):653-661.

· Sharrock N, Heerdt P, Go G, Ho M and Salvati E. Changes in augmentation wave measurements with hypotensive epidural anesthesia; 2006; New York City: American Society of Hypertension.

· Sharrock N, Go G and Sculco TP. Effect of Thigh Tourniquet Deflation on Hemodynamic Variables Assessed by Measuring Suprasystolic Brachial Artery Signals; 2006; Madrid, Spain: European Society of Anaesthesiology.

· Sharrock N, Go G and Sculco TP. Effect of Epidural Anesthesia on Hemodynamic Variables Assessed by Measuring Suprasystolic Brachial Artery Signals; 2006; Madrid, Spain: European Society of Anaesthesiology.

· Sharrock NE, North RA, Taylor RS, Lowe A and Roldan DN. Is preeclampsia associated with decreased vascular compliance? 2004; Las Vegas, NV: American Society of Anesthesiologists.

· Jueslgaard P, Haraldsted VY, Go G and Sharrock NE. Determination of arterial compliance by measurements of suprasystolic signals during hypotensive epidural anaesthesia; 2004; Paris, France: 13th World Congress of Anaesthesiologists.

· Isnardi D, Andrews P, Lowe A. Arterial compliance in acute brain injured patients. 2003; Amsterdam: 16th ESICM Annual Congress.

pulsecor (technology)

· El-Aklouk E, Al-Jumaily AM, Lowe A. Acoustic Response of the Human Arteries, Biomedical Applications of Vibration and Acoustics for Imaging, Characterization, and Diagnostics, ASME Press (accepted for publication, 2008)

· El-Aklouk E, Al-Jumaily AM, Lowe A. Non-Invasive Detection of Arterial Stiffness using Brachial Artery Pressure Waves, Medical Sciences Congress, Queenstown, 27-30 November 2007.

· Moorkerjee A, Al-Jumaily AM, Lowe A. Cardiovascular Performance from Arterial Waves: Role of Mathematical Models in the Development of Non-Invasive Techniques. Medical Sciences Congress, Queenstown, 27-30 November 2007.

· El-Aklouk E, Al-Jumaily A.M, Lowe. A, Brachial Wave Measurements for Artery Stiffness Detection, 1^st Congress of Asian Society of Cardiovascular Imaging, April 27-28, Asian Medical Centre, Seoul, Korea.

· El-Aklouk E, Al-Jumaily AM, Lowe A. Acoustic Wave Technology as a Diagnostic Tool for Cardiovascular Disease, The World Congress on Medical Physics and Biomedical Engineering 2006(WC2006), August 27 to September 1, 2006, Seoul, Korea.

Repeatability: pulsecor’s augmentation index is repeatable and gives information additional to blood pressure. (Download white paper.)

Pharmacological Sensitivity: pulsecor’s central arterial compliance index changes more significantly than blood pressure in response to vasoactive drugs, and can help to distinguish between different causes of changes in blood pressure. (Download slides.)

Research Context: Current thinking is that arterial stiffness improves prediction of cardiovascular events. But does making arterial stiffness a treatment end-point improve outcomes? (Download white paper.)

Arterial Stiffness and Age: It is well-known that arteries becomes stiffer with advancing age. Pulsecor’s measurements also show these trends.